[size=4][b]Treat Gout - New Gout Drugs - Pegloticase Continues Its Hopeful Path[/b][/size][hr]May 2008 the U.S. based company developing Pegloticase made another upbeat statement assessment of what they have learnt in its Phase 3 and open label extension trials. Note that Pegloticase still awaits approval from medical authorities so I am writing here about a new gout drug that is still under development.
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension. It is only if you find some usage for the matter described here on Treat Gout that we will feel the efforts put in writing on Treat Gout fruitful. So make good usage of it!
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009. :o.
The world gout natural cure remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
[list][*]31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial.[*]It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.[*]Looking for something logical on Gout Drugs, we stumbled on the information provided here.[*]Look out for anything illogical here. [/list]
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
<strong>TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS </strong> Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
[size=large][b]Has Been Having a Decent Degree of Success[/b][/size][hr]<strong>Elimination of gout attacks </strong>In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.
[list][*]<strong>SIDE EFFECTS </strong> Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients.[*]The developing company has said that most were mild, moderate, or controllable.[*]But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes. [/list]
[size=large][b]Gout is Also Known as Crystal-Induced Arthritis[/b][/size][hr]It is a medical condition that sets in when uric acid crystals collect on the joints. At the first stage, gout usually affects the large joints in the big toe. Gradually it can spread to other parts of the body, like the ankles, the instep, the heels and the knees, the wrists and fingers of the hand and the elbows. In severe cases, even the shoulders, hips or spine can be affected. Gout does not spread from one joint to the next. Uric acid is a metabolic end product that is formed at the time the body breaks down purines present in certain food items. In normal conditions, the uric acid gets dissolved in the blood and gets eliminated from the body through the kidneys into the urine. However, people having a propensity for gout have such high levels of uric acid in their blood that the acid precipitates out in the form of crystals. The crystals get accumulated on the joints and other tissues, leading to inflammation and excruciating pain. A chronic condition can lead to the formation of tophi lumps formed under the skin due to large deposits on severely affected joints of the elbow, fingers and toes, and even on the external pinna.
Another medical condition, referred to as the pseudo-gout, results from the deposits of calcium-based crystals in the joints. In almost 90 percent of incidences of gout, men over the age of 40 and menopausal women are affected. An "episode" often takes place during the night. Within 12 to 24 hours of the onset, the afflicted joint becomes severely inflamed and starts to ache rigorously. The gout attack usually lasts about five to 10 days. Just as a book shouldn't be judged by its cover, we wish you read this entire article on Gout Attack before actually making a judgement about Gout Attack. :o.
[b]The probable causes of gout include: Genetic defects in metabolism resulting in hyper-production and retention of uric acid in the blood [/b]
[b]Kidney failure leading to hampered elimination of uric acid from the body Diuretic medications employed in the treatment of heart failure and diabetes.[/b]
[b]Arthritis that develops in 1 day Attack of arthritis in only one joint, usually the toe, ankle, or knee A painful joint that is swollen, red, and warm
[/b]
[i]The Signs and Symptoms of Gout include: Hyperuricemia Presence of uric acid crystals in joint fluid More than one attack of acute arthritis :o[/i]
Gout is one of the most common forum osteoarthritis (joint inflammation). Gout is condition that results from crystals of uric acid depositing in tissues of the body. Gout usually affects the first metatarsal phalangeal joint of the big toe (hallux) or the ankle joints. Gout most often affects the big toe but can also affect the ankle, knee, foot, hand, wrist and elbow. Approximately one million people in the United States suffer from attacks of gout. Gout is nine times more common in men than in women. It predominantly attacks males after puberty, with a peak age of 75. In women, gout attacks usually occur after menopause.
To prevent future attacks, your doctor can prescribe a medicine to reduce uric acid buildup in your blood. Changing the way you eat can help you conduct your gout. Eat a healthy mix of foods so you get the nutrients you need. Limit foods like meat, fish, and beer. Drink plenty of water and other fluids.Life style changes such as limiting alcohol consumption, and limiting meals with meats and fish rich in purines can also be helpful in controlling gout. Weight loss may be very important this condition. You should also avoid certain animal proteins, such as: seafood; liver; kidney; heart; gizzard; sweetbreads; meat extracts; and gravy.
[size=large][b]Occurs More Frequently in Countries that Have a High Standard of Living[/b][/size][hr]The most common sign of gout is a nighttime attack of swelling, tenderness, redness, and sharp pain in your big toe. There may also be the feeling that the skin around the area is stretching or tearing. There seem to be a number of factors that can cause people to develop gout. Some medications can prevent uric acid from leaving the body. Cyclosporine which is a medication used to suppress the body's immune system and prevent rejection after organ transplant, also increases the risk for developing gout. This can cause a build up of uric acid crystals.
[size=large][b]Alcohol and Certain Foods can Trigger a Gout Attack[/b][/size][hr]Events such as strokes, heart attacks or surgery may also cause gout. Gout is strongly associated with obesity, hypertension, hyperlipidemia and diabetes. Because of genetic factors, gout tends to run in some families. A variety of treatments can help you manage your gout. Traditionally treatment for acute gout has consisted of colchicine , which can be effective if given early in the attack. Gout often is treated with nonsteroidal anti-inflammatories (NSAIDs) such as naproxen (e.g., Anaprox, Naprosyn) and indomethacin (e.g., Indocin), usually for 3-7 days.
This suggests that progression of the disease may be contained in difficult-to-treat cases, and therefore may not cause other medical conditions such as kidney stones heart disease and hypertension. It is only if you find some usage for the matter described here on Treat Gout that we will feel the efforts put in writing on Treat Gout fruitful. So make good usage of it!
Quote:<strong>HOW PEGLOTICASE WORKS </strong> What makes Pegloticase a very interesting, and more importantly, a hopeful new gout drug, is the way it works. All drugs used in gout try to cure or alleviate the disease by reducing the body's uric acid (UA) levels. They do this by either inhibiting its production or making it easier to remove.
Pegloticase is getting closer to an application for approval by the U.S. FDA. Its developers hope to apply for a Biologics Licence Application in September 2008, and begin marketing it in 2009. :o.
The world gout natural cure remedies, uric acid's removal can be improved by making it more soluble. This is achieved by drinking lots of water and by raising body pH levels in various ways.
Other encouraging statements were that all extension trial patients who had responded earlier to treatment and who were on the every two week course maintained normal uric acid levels, (some were new joiners). 70% of those on an every four week course who had responded earlier to treatment, maintained normal uric acid levels.
[list][*]31% of patients who had not reduced tophi at the end of these phase 3 trials did show tophi reduction in the extension trial.[*]It would seem that the longer a gout sufferer is able to take Pegloticase the more successful it may be, in tophi cases at least.[*]Looking for something logical on Gout Drugs, we stumbled on the information provided here.[*]Look out for anything illogical here. [/list]
May was a good month for gout sufferers. Febuxostat, (EU trade/brand name Adenuric), the first new major drug medication for gout in over 40 years, was approved for marketing in member countries of the European Union.
Pegloticase's answer to the excess uric acid level problem is to remove it by ingeniously converting uric acid into something else, a substance called Allantoin. Allantoin is more soluble and better excreted than uric acid. The principle comes from the way most animals do it. They do it by converting UA to Allantoin, but this is something humans cannot do naturally. Hence the formulation of Pegloticase.
<strong>TRIAL SUCCESS WITH DIFFICULT TO TREAT GOUT PATIENTS </strong> Pegloticase is significant because its trials have focused on gout patients who have not had success with other gout drugs, or who have medical conditions which prohibit the use of them. Thus it has been tackling harder-to-treat gout cases, not the easier ones. Hard to treat cases are a significant percentage of the gout sufferer universe.
[size=large][b]Has Been Having a Decent Degree of Success[/b][/size][hr]<strong>Elimination of gout attacks </strong>In its most recent statement the developing company's most significant remark was that the extension trial group receiving Pegloticase every two weeks, there were only four gout attacks among those who had been administered Pegloticase (8 mg) every fortnight for two months, in subsequent months. And none in this group had a gout attack after five months of Pegloticase treatment, in following months. All were patients who had been through a phase 3 trial.
[list][*]<strong>SIDE EFFECTS </strong> Of course Pegloticase has caused side effects, in the extension trial in about 1 in 5 patients.[*]The developing company has said that most were mild, moderate, or controllable.[*]But in some cases more severe side effects have been described as including chest and back pains, muscle cramps, sweating and flushes. [/list]
[size=large][b]Gout is Also Known as Crystal-Induced Arthritis[/b][/size][hr]It is a medical condition that sets in when uric acid crystals collect on the joints. At the first stage, gout usually affects the large joints in the big toe. Gradually it can spread to other parts of the body, like the ankles, the instep, the heels and the knees, the wrists and fingers of the hand and the elbows. In severe cases, even the shoulders, hips or spine can be affected. Gout does not spread from one joint to the next. Uric acid is a metabolic end product that is formed at the time the body breaks down purines present in certain food items. In normal conditions, the uric acid gets dissolved in the blood and gets eliminated from the body through the kidneys into the urine. However, people having a propensity for gout have such high levels of uric acid in their blood that the acid precipitates out in the form of crystals. The crystals get accumulated on the joints and other tissues, leading to inflammation and excruciating pain. A chronic condition can lead to the formation of tophi lumps formed under the skin due to large deposits on severely affected joints of the elbow, fingers and toes, and even on the external pinna.
Another medical condition, referred to as the pseudo-gout, results from the deposits of calcium-based crystals in the joints. In almost 90 percent of incidences of gout, men over the age of 40 and menopausal women are affected. An "episode" often takes place during the night. Within 12 to 24 hours of the onset, the afflicted joint becomes severely inflamed and starts to ache rigorously. The gout attack usually lasts about five to 10 days. Just as a book shouldn't be judged by its cover, we wish you read this entire article on Gout Attack before actually making a judgement about Gout Attack. :o.
[b]The probable causes of gout include: Genetic defects in metabolism resulting in hyper-production and retention of uric acid in the blood [/b]
[b]Kidney failure leading to hampered elimination of uric acid from the body Diuretic medications employed in the treatment of heart failure and diabetes.[/b]
[b]Arthritis that develops in 1 day Attack of arthritis in only one joint, usually the toe, ankle, or knee A painful joint that is swollen, red, and warm
[/b][i]The Signs and Symptoms of Gout include: Hyperuricemia Presence of uric acid crystals in joint fluid More than one attack of acute arthritis :o[/i]
Gout is one of the most common forum osteoarthritis (joint inflammation). Gout is condition that results from crystals of uric acid depositing in tissues of the body. Gout usually affects the first metatarsal phalangeal joint of the big toe (hallux) or the ankle joints. Gout most often affects the big toe but can also affect the ankle, knee, foot, hand, wrist and elbow. Approximately one million people in the United States suffer from attacks of gout. Gout is nine times more common in men than in women. It predominantly attacks males after puberty, with a peak age of 75. In women, gout attacks usually occur after menopause.
To prevent future attacks, your doctor can prescribe a medicine to reduce uric acid buildup in your blood. Changing the way you eat can help you conduct your gout. Eat a healthy mix of foods so you get the nutrients you need. Limit foods like meat, fish, and beer. Drink plenty of water and other fluids.Life style changes such as limiting alcohol consumption, and limiting meals with meats and fish rich in purines can also be helpful in controlling gout. Weight loss may be very important this condition. You should also avoid certain animal proteins, such as: seafood; liver; kidney; heart; gizzard; sweetbreads; meat extracts; and gravy.
[size=large][b]Occurs More Frequently in Countries that Have a High Standard of Living[/b][/size][hr]The most common sign of gout is a nighttime attack of swelling, tenderness, redness, and sharp pain in your big toe. There may also be the feeling that the skin around the area is stretching or tearing. There seem to be a number of factors that can cause people to develop gout. Some medications can prevent uric acid from leaving the body. Cyclosporine which is a medication used to suppress the body's immune system and prevent rejection after organ transplant, also increases the risk for developing gout. This can cause a build up of uric acid crystals.
[size=large][b]Alcohol and Certain Foods can Trigger a Gout Attack[/b][/size][hr]Events such as strokes, heart attacks or surgery may also cause gout. Gout is strongly associated with obesity, hypertension, hyperlipidemia and diabetes. Because of genetic factors, gout tends to run in some families. A variety of treatments can help you manage your gout. Traditionally treatment for acute gout has consisted of colchicine , which can be effective if given early in the attack. Gout often is treated with nonsteroidal anti-inflammatories (NSAIDs) such as naproxen (e.g., Anaprox, Naprosyn) and indomethacin (e.g., Indocin), usually for 3-7 days.
[/list]